生物钟是生命活动的内在节律。其中，周期约为24小时的近日节律与人类健康的关系最为密切，受到广泛研究。该节律广泛存在于动植物体内，甚至体外培养的细胞中。在哺乳动物，生物钟由一组时钟蛋白驱动，它们以周期的方式控制着成百上千其他基因的表达，进而影响纷繁的生理和生化过程。人们早就知道长期的昼夜节律紊乱是众多常见疾病的危险因素，包括糖尿病、心血管疾病、炎症、肿瘤等等，但机制远不明了，也鲜有针对生物钟的治疗或辅助治疗措施。我们主要致力于研究生物钟，尤其是紊乱的生物钟，在行为、衰老，以及重大疾病发生发展中的作用，并探索可能的干预措施。
主要研究方向：
1.生物钟在发育，衰老，以及行为学中的作用
2.生物钟紊乱与重大疾病发生发展的关系
3.探索生物钟紊乱的药物或非药物干预措施
负责人主要学术任职：
期刊编委
Frontiers in Pharmacology (Editorial Board) |
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Journal of Pharmacological Reports (Editorial Board) |
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PPAR Research (Guest Editor, 2013-2014) |
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Scientific Reports (Editorial Board) |
期刊及基金评审人
Annual Research & Review in Biology |
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BMC Endocrine Disorders |
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Cell Physiology and Biochemistry |
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Endocrinology & Metabolic Syndrome |
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Frontiers in Pharmacology |
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International Journal of Clinical and Experimental |
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International Journal of Obesity |
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Journal of Gerontology & Geriatric Research |
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Molecular Biology Report |
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Oncology Reports |
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Oncotarget |
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Plos One |
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PPAR Research |
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Scientific Reports |
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以色列科学基金 |
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中国国家自然科学基金委 |
专业学会会员
American Heart Association, USA (AHA)
American Physiological Society, USA (APS)
The Society for Research on Biological Rhythms, USA (SRBR)
中国生理学会会员
中国细胞生物学会生物节律分会委员
负责人发表各类学术文章40余篇（不含会议论文），包括Circulation，Science Translational Medicine，PNAS等国际著名学术期刊，累积影响因子超过200，论文他引1500余次。现担任Scientific Reports，Frontiers in Pharmacology等期刊的编委，以及10余个国际学术期刊及基金会的评审人，多次受邀为Frontiers in Pharmacology及PPAR Research等期刊组织专刊，撰写特邀综述及评述，多次受到包括新华社、TheScientist、Men's Health、Circulation News等在内的国内外媒体的采访，多项工作得到了媒体报道和大量转载。
Selected publications in recent 5 years,
1. Guangrui Yang#, Jiayang Zhang#, Tingting Jiang, James Monslow, Soon Yew Tang, Leslie Todd, Ellen Puré, Lihong Chen*, Garret FitzGerald*; Bmal1 deletion in myeloid cells attenuates atherosclerotic lesion development and restrains abdominal aortic aneurysm formation in hyperlipidemic mice, Arteriosclerosis, Thrombosis, & Vascular Biology. In press
2. Tingting Jiang#, Shuang Ji#, Guangrui Yang, Lihong Chen*：Research advances in relationship between biological clock and cardiovascular diseases. Acta Physiologica Sinica. 2019 Oct 25;71(5):783-791. DOI: 10.13294/j.aps.2019.0066. [PMID: 31646332]
3. Lihong Chen#*, Guangrui Yang#, Tingting Jiang#, Soon Yew Tang, Tao Wang, Qing Wan, Miao Wang and Garret A. FitzGerald*: Myeloid cell mPges-1 depletion attenuates mortality without affecting remodeling after acute myocardial infarction in mice. Journal of Pharmacology and Experimental Therapeutics. 2019 Jul;370(1):18-24. DOI: 10.1124/jpet.118.256057. [PMID: 30992314]
4. 张嘉阳，季爽，陈丽红*，杨光锐*：肾脏生物钟研究概况。生理科学进展(Progress in Physiological Sciences). 2019; 50(5): 386-390.
5. Guangrui Yang#*, Lihong Chen#, Jiayang Zhang, Baoyin Ren, and Garret A. FitzGerald*: Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions. JCI insight. 2019 Apr 11;5. DOI: 10.1172/jci.insight.125133. [PMID: 30973828]
6. Lihong Chen#, Guangrui Yang#, Jiayang Zhang, Baoyin Ren, Soonyew Tang, Xuanwen Li, Garret A. FitzGerald*: Time-dependent hypotensive effect of aspirin in mice. Arteriosclerosis, Thrombosis, & Vascular Biology. 2018 Dec;38(12):2819-2826. DOI: 10.1161/ATVBAHA.118.311296. [PMID: 30571171]
7. Hu Hua#, Xuhua Ge#, Mengqiu Wu, Chunhua Zhu, Lihong Chen, Guangrui Yang, Yue Zhang, Songming Huang, Aihua Zhang*, and Zhanjun Jia*: Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation. Kidney & Blood Pressure Research. 2018;43(4):1297-1309. DOI: 10.1159/000492589. [PMID: 30099449]
8. Jie Yin#, Weiwei Xia#, Yue Zhang, Guixia Ding, Lihong Chen, Guangrui Yang, Songming Huang, Zhanjun Jia*, and Aihua Zhang*: Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells. Heart and Vessels. 2018 Nov;33(11):1411-1422. DOI: 10.1007/s00380-018-1190-9. [PMID: 29796776]
9. Yibo Zhuang#, Chenhu Wang#, Chunfeng Wu, Dan Ding, Fei Zhao, Caiyu Hu, Wei Gong, Guixia Ding, Yue Zhang, Lihong Chen, Guangrui Yang, Chunhua Zhu, Aihua Zhang, Zhanjun Jia, and Songming Huang*: Mitochondrial oxidative stress activates COX-2/mPGES-1/PGE2 cascade induced by albumin in renal proximal tubular cells. Oncotarget. 2018 Jan 12;9(10):9235-9245. DOI: 10.18632/oncotarget.24187. [PMID: 29507686]
10. Jing Wang, Min Liu, Xiaoyan Zhang, Guangrui Yang*, and Lihong Chen*: Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins & other lipid mediators. 2018 Jan;134:1-6. DOI: 10.1016/j.prostaglandins.2017.10.006. [PMID: 29104159]
11. Carsten Skarke*, Nicholas F. Lahens, Seth D. Rhoades, Amy Campbell, Kyle Bittinger, Aubrey Bailey, Christian Hoffmann, Randal S. Olson, Lihong Chen, Guangrui Yang, Thomas S. Price, Jason H. Moore, Frederic D. Bushman, Casey S. Greene, Gregory R. Grant, Aalim M. Weljie, and Garret A. FitzGerald*: A pilot characterization of the human chronobiome. Scientific Reports. 2017 Dec 7;7(1):17141. DOI: 10.1038/s41598-017-17362-6. [PMID: 29215023]
12. Yibo Zhuang#, Zhanjun Jia#, Caiyu Hu, Guixia Ding, Xintong Zhang, Yue Zhang, Guangrui Yang, Rajeev Rohatgi, Songming Huang, John Ci-Jiang He*, and Aihua Zhang*: Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb. Oncotarget. 2017 Sep 29; 8(44): 75808–75821. DOI: 10.18632/oncotarget.10257 [PMID: 29100270]
13. Guangrui Yang, and Lihong Chen*: An update of microsomal prostaglandin E synthase-1 and PGE2 receptors in cardiovascular health and diseases. Oxidative Medicine and Cellular Longevity. 2016;2016:5249086. DOI: 10.1155/2016/5249086 [PMID: 27594972]
14. Guangrui Yang#, Lihong Chen#, Gregory R. Grant, Georgios Paschos, Wen-Liang Song, Erik S. Musiek, Vivian Lee, Sarah C. McLoughlin, Tilo Grosser, George Cotsarelis, and Garret A. FitzGerald*: Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Science Translational Medicine. 2016 Feb 3;8(324):324ra16. DOI: 10.1126/scitranslmed.aad3305 [PMID: 26843191]
15. Jing Yu, Wei Gong, Yimei Wu, Shuzhen Li, Yiyun Cui, Yifei Ma, Yue Zhang, Guangrui Yang, Songming Huang, Zhanjun Jia, and Aihua Zhang*: mPGES-1-derived PGE2 contributes to adriamycin-induced podocyte injury. American Journal of Physiology - Renal Physiology. 2016 Mar 15;310(6):F492-8. DOI: 10.1152/ajprenal.00499.2015 [PMID: 26739892]
16. Guangrui Yang: Pharmacology on time. Journal of Pharmacological Reports. 2015;1,e001. DOI:10.4172/jpr.1000e101 (创刊号特邀评述)
17. Guangrui Yang*, Han Wang, and Erquan Zhang: Editorial: Therapeutic implications of circadian rhythms. Frontiers in Pharmacology. 2015 Aug 19;6:175. DOI: 10.3389/fphar.2015.00175 [PMID: 26347653]
18. Garret A. FitzGerald*, and Guangrui Yang, Georgios Paschos, Xue Liang, and Carsten Skarke: Molecular clocks and the human condition: approaching their characterization in human physiology and disease. Diabetes, obesity & metabolism. 2015 Sep;17 Suppl 1:139-42. DOI: 10.1111/dom.12526 [PMID: 26332979]
19. Anne M. Curtis#, Caio T. Fagundes#, Guangrui Yang#, Eva M. Palsson-McDermott, Paulina Wochal, Anne F. McGettrick, Niamh H. Foley, James O. Early, Lihong Chen, Hanrui Zhang, Chenyi Xue, Sarah S. Geiger, Karsten Hokamp, Muredach P. Reilly, Andrew N. Coogan, Elena Vigorito, Garret A. FitzGerald*, and Luke A. J. O’Neill*: Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proceedings of the National Academy of Sciences. 2015 Jun 9;112(23):7231-6. DOI: 10.1073/pnas.1501327112 [PMID: 25995365]
20. Lihong Chen* and Guangrui Yang*: Recent advances in circadian rhythms in cardiovascular system. Frontiers in Pharmacology. 2015 Apr 1;6:71. DOI: 10.3389/fphar.2015.00071 [PMID: 25883568]
